The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
fei xiao xi bao fei ai huan zhe de xin xuan ze - yan suan ai ke ti ni
Author(s): 
Pages: 121-124
Year: Issue:  2
Journal: JOURNAL OF PHARMACEUTICAL RESEARCH

Keyword:  盐酸埃克替尼小分子酪氨酸激酶抑制剂非小细胞肺癌;
Abstract: 盐酸埃克替尼是第一个国产靶向治疗非小细胞肺癌,口服的小分子酪氨酸激酶抑制剂.与吉非替尼和厄洛替尼具有相似的作用机制,其特点是在不同水平特异性、竞争性地结合在EGFR激酶功能区,抑制其激酶活性从而阻断癌细胞增殖、转移等相关信号的传导.临床用于治疗既往接受过1种或2种化疗的局部晚期或转移的非小细胞肺癌.本文对化学结构和作用机制、基础药理学和药效学、临床前研究、临床研究、耐受性和安全性、上市后至现阶段专家共识等方面对其做一综述.
Related Articles
No related articles found