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Detection of glibenclamide illegally mixed into traditional Chinese antidiabetic preparations by HPLC
Author(s): 
Pages: 522-523
Year: Issue:  9
Journal: QILU PHARMACEUTICAL AFFAIRS

Keyword:  降糖中药制剂格列本脲高效液相色谱法;
Abstract: 目的 建立降糖中药制剂中所添加的格列本脲的定性、定量检测方法.方法 采用高效液相色谱法.色谱柱:C18柱(4.6 mm×250 mm,5 μm);流动相:0.1 mol·L-1磷酸二氢钾-乙腈(53:47);流速1.0 mL·min-1;柱温35 ℃;检测波长300 nm.结果 1种供试品中检出格列本脲.格列本脲浓度在0.051~1.014 4 mg·mL-1范围内,峰面积与进样量呈良好的线性关系,相关系数r=1.000,平均回收率为99.97%,RSD为1.3%.结论 本方法 简便易行、准确可靠,可作为监测降糖中药制剂非法添加格列本脲的有效方法.
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