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Improvoed synthesis of sibutramine hydrochloride
Author(s): 
Pages: 298-300
Year: Issue:  5
Journal: Qilu Pharmaceutical Affairs

Keyword:  盐酸西布曲明减肥药合成改进;
Abstract: 目的 研究盐酸西布曲明适合工业化大生产的方法.方法 以对氯氯苄为原料,经取代、环合、加成、还原、二甲基化及成盐等反应合成盐酸西布曲明,并对反应条件进行了改进和优化.结论 工艺经改进和优化后,反应条件温和,操作简便,工艺稳定,总收率达到57.8%,大幅度的降低了生产成本,更加适合工业化生产.
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