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Synthetic of tolterodine tartrate
Author(s): 
Pages: 301-303
Year: Issue:  5
Journal: Qilu Pharmaceutical Affairs

Abstract: 目的 合成酒石酸托特罗定.方法 以肉桂酸和对甲苯酚为起始原料,经环合、甲基化、还原、对甲苯磺酰化、胺化、脱甲基、拆分七步反应合成酒石酸托特罗定.结果 与结论总收率为16.5%.该合成路线简洁,反应步骤少,适宜工业化生产.
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