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Determination of omeprazole in dog plasma by HPLC
Author(s): 
Pages: 351-352
Year: Issue:  6
Journal: QILU PHARMACEUTICAL AFFAIRS

Keyword:  奥美拉唑高效液相色谱法狗血浆;
Abstract: 目的 建立奥美拉唑狗血药浓度高效液相色谱测定方法.方法 色谱柱为Hypersil C18(200mm×4.0mm,5μm),流动相为甲醇-水(65∶35),流速为0.8mL·min-1,紫外检测器波长为302nm,乙奈酚为内标,血样用正己烷提取,进样量50μL,柱温:30℃,峰面积比定量.结果 标准曲线线性范围25~500ng·mL-1,r=0.9984,血样加内标绝对提取回收率80.3%~94.0%,相对回收率95.0%~95.7%,最低检测限25ng·mL-1.结论 本方法简便、快速、准确、重现性好,可适用于奥美拉唑药代动力学研究.
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