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Evaluation on effect and toxicity of arsenic trioxide in the treatment of middle-late hepatocarcinoma by transcatheter arterial chemoembolization
Author(s): 
Pages: 1161-1162
Year: Issue:  9
Journal: ZHEJIANG CLINICAL MEDICAL JOURNAL

Keyword:  亚砷酸/三氧化二砷介入治疗原发性肝癌;
Abstract: 目的 评价亚砷酸联合化疗药物及超液化碘油行肝动脉化疗栓塞术(TACE)治疗中晚期肝癌的疗效和不良反应.方法 中晚期肝癌共65例随机分2组, A组32例行肝动脉灌注羟基喜树碱20mg或阿霉素50mg、顺铂60 mg、超液化碘油5~20ml, B 组33例在上述化疗药基础上加用亚砷酸20mg.观察其疗效与不良反应.结果 A 组客观有效率(CR+PR)达43.8%(14/ 32) ,获益率(CR+PR+NC)达71.2%(23/32);B 组客观有效率达51.1%(17/33),获益率为93.9%(31/33),两组客观有效率比较无显著性差异(P>0.05),获益率比较有显著性差异(P<0.05).患者血清AFP水平,A、B组治疗前后比较有非常显著性差异,A、B组治疗后比较有显著性差异.不良反应主要为骨髓抑制、恶心呕吐、疼痛、发热,两组均无Ⅳ度不良反应,无治疗相关性死亡.结论 亚砷酸联合化疗药及超液化碘油行TACE治疗中晚期肝癌有较好疗效,不良反应较小,是肝癌介入治疗用药的较佳选择,值得临床推广.
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