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Relationship between CD62p、CD63 and diabetic peripheral neuropathy in type Ⅱ diabetes patients
Author(s): 
Pages: 1165-1166
Year: Issue:  9
Journal: ZHEJIANG CLINICAL MEDICAL JOURNAL

Keyword:  2型糖尿病糖尿病周围神经病变CD62p、CD63;
Abstract: 目的 探讨CD62p、CD63与糖尿病周围神经病变(DPN)的关系.方法 用流式细胞术测定59例2型糖尿病患者CD62p、CD63,使用Nicolet Viking IVD 肌电图诱发电位仪测定周围神经传导速度(NCV),肌电图正常者为非DPN(A组,25例),神经电生理异常者为DPN(B组,34例).健康对照组26例.结果 CD62p、CD63的水平在糖尿病与对照组比较有显著差异(P<0.001,P<0.01),B组与A组有显著差异(P<0.05,P<0.05),直线相关分析显示CD62p与CD63(r=0.564,P<0.001)、FPG(r=O.402,P<0.01)呈正相关,与左腓MNCV(r=-0.320,P<0.05)、右腓MNCV(r=-0.299,P<0.05)、左尺MNCV(r=-0.407,P<0.01)、右尺SNCV(r=-0.382,P<0.05)呈负相关,与年龄、病程、GHB、TG、TC、BMI等无相关,CD63与FPG(r=O.623,P<0.001)呈正相关,与左腓MNCV(r=-0.377,P<0.01)、右腓MNCV(r=-0.285,P<0.05)、右尺SNCV(r=-0.378,P<0.05)呈负相关,与其余因素无相关.结论 CD62p、CD63表达率可能是糖尿病周围神经病变发生与发展的一个预测指标.
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