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Synthesis of Nitrofurantoin
Author(s): 
Pages: 43-44
Year: Issue:  1
Journal: QILU PHARMACEUTICAL AFFAIRS

Keyword:  呋喃妥因抗菌药合成1-氨基海因盐酸盐糠醛;
Abstract: 目的 确定一种新的呋喃妥因合成工艺.方法 以糠醛、1-氨基海因盐酸盐、浓硫酸、硝酸为原料,选择适当的混酸浓度,并用DMF重结晶制得呋喃妥因.结果 符合《中国药典》2005年版质量要求.结论 本工艺收率较高,成本相对较低,产品质量稳定并符合法定标准.
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