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Protective effect of glucoside of Picrorhiza scrophulariflora Pennell on acute chemical-induced liver injury mice
Author(s): 
Pages: 681-682
Year: Issue:  11
Journal: QILU PHARMACEUTICAL AFFAIRS

Keyword:  胡黄连苷四氯化碳肝损伤小鼠乙醇;
Abstract: 目的 研究胡黄连苷(GP)对小鼠急性化学性肝损伤的保护作用.方法 灌胃给予乙醇或腹腔注射四氯化碳(CCl4)以制备小鼠急性化学性肝损伤模型,检测血清丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)活性﹑肝脏重量指数.结果 连续6d灌胃给予15.0﹑30.0﹑60.0 mg/(kg·d) GP能明显抑制肝损伤小鼠血清ALT﹑AST 活性的升高(P<0.05),减轻增加的肝脏重量指数.结论 GP对四氯化碳及乙醇引起的小鼠急性肝损伤具有保护作用.
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