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Effect of Nutrient Restriction on Triglyceride Content and Bone Mineral Density in Aged Mice
Author(s): 
Pages: 28-30
Year: Issue:  1
Journal: LABORATORY ANIMAL AND COMPARATIVE MEDICINE

Keyword:  营养衰老骨密度甘油三酯;
Abstract: 目的研究营养摄入限制对老年小鼠脂代谢及骨代谢的影响作用.方法以12月龄老年雄性KM小鼠为研究对象,实施12周每日限食30%总能量的限食方案,另取3月龄、7月龄及同龄雄性KM小鼠作为青年、成年及老年对照组,观测体重动态变化,并测定甘油三酯(TG)和骨密度.结果老年限食组在限食第2、3周的体重下降幅度最为显著,此后下降趋势减缓;老年限食组甘油三酯值低于老年对照组(P<0.05),骨密度值与老年对照组、成年对照组相比,无显著差异.结论30%的营养摄入限制能显著降低老年小鼠血中甘油三酯,对骨密度的作用则依赖于骨代谢综合影响因素.
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